People in the Burns Lab
Kathleen H. Burns, M.D., Ph.D.
Principal Investigator
Dr. Burns received her M.D. and Ph.D. in Molecular and Human Genetics from Baylor College of Medicine. She completed a clinical pathology (CP) residency and hematopathology fellowship at Johns Hopkins University School of Medicine, and served as chief resident. Thereafter, Dr. Burns joined the faculty at Johns Hopkins and progressed through the academic ranks to Professor. She served as Vice Chair for Research and Programs in the Pathology Department and Director of the school-wide Physician Scientist Training Program (PSTP). She was recruited to Dana-Farber as Chair of the Department of Pathology in 2020.
Her honors and invited lectures include a Career Award for Medical Scientists from the Burroughs Wellcome Fund, election to the American Society of Clinical Investigation, the Scriver Family Visiting Professorship in Genetics from McGill University, the Daria Haust Lecturer of Pathology at Queen's University, the Inaugural Thomas Wheeler Lecture at Baylor College of Medicine Department of Pathology, and the George E. Peacock Memorial Lecture at the Department of Pathology at University of Texas Southwestern. Kathy has given Keynote addresses for meetings organized by Cold Spring Harbor Laboratories, Cold Spring Harbor Asia, and Gordon Research Conferences.
Wen-Chih Cheng, Ph.D. Senior Scientist
Dr. Cheng received her Ph.D. from the Johns Hopkins University where she studied the role of mitochondrial proteins in programmed cell death pathways. Her postdoctoral research at both Johns Hopkins University and University of Maryland focused on the role of microRNAs in human leukemias and stem cell biology. Prior to joining DFCI, she was a research scientist developing a novel diagnostic technology at Scanogen Inc.
Current research: Wen is leading projects to understand the interplay between the LINE-1 retrotransposon and cancer, especially where LINE-1 biology can be used to develop new cancer diagnostics and therapeutics. She is developing new reagents for ORF1p detection and investigating translational mechanisms regulating ORF2p production.
Aidan Burn, Ph.D. Scientist II
Dr. Burn received his Ph.D. in Genetics from Tufts University where he studied endogenous retroviruses. His research focused on characterizing the transcriptional activity of HERVs in normal tissue and how that activity varies between different tissues, individuals, and proviruses.
Current research: Aidan is leading our lab’s work on the NIH SMaHT (Somatic Mosaicism across Human Tissue) project : developing new ways to identify LINE-1 insertions and measure LINE-1 methylation to gain insight into how it shapes the genome in tissues.
Carolyn "Carlie" Hruban, Ph.D. Postdoctoral FeIIow
Dr. Hruban received her Ph.D. in Human Genetics and Genomics at Johns Hopkins University School of Medicine where she studied circulating tumor DNA dynamics in patients undergoing cancer treatment, through whole genome genomics and fragmentomics approaches.
Current research: Carlie is implementing further analyses of the LINE-1 ORF1p biomarker and testing its potential in a variety of clinical liquid biopsy settings.
Jennifer Karlow, Ph.D. Postdoctoral Fellow
Dr. Karlow received her Ph.D. in Computational and Systems Biology at Washington University where she studied how cells undergo epigenetic reprogramming across cancer types and through tumor progression into metastasis.
Current research: Jennifer is studying how LINE-1 expression alters cell genomes and transcriptomes in tumor evolution. Jennifer's work is supported by a fellowship from the American Cancer Society supported by the Cancer Research Racquet.
Tomohiro Kitano, D.M.D., Ph.D. Postdoctoral Fellow
Dr. Kitano received his D.M.D. from Nippon Dental University in Japan. He completed his residency in Oral and Maxillofacial Surgery at Gunma University Hospital and received his Ph.D. from Keio University, where he focused on the role of endogenous retroviruses in mouse preimplantation development.
Current research: Tomohiro is researching the landscape of transposable element expression in oral cancers and leukoplakia, and their potential contributions to pathogenesis in these diseases.
Esin Isik, Ph.D. Postdoctoral Fellow
Dr. Isik received her Ph.D. in Cancer Biology from the University of Zurich where she studied the molecular mechanisms underlying the resolution of transcription-dependent replication stress.
Current research: Esin is investigating LINE-1 retrotransposition as an endogenous source of DNA replication stress and genomic instability. Esin’s work is supported by a Postdoc Mobility fellowship from the Swiss National Science Foundation.
Esin Isik, Ph.D. Postdoctoral Fellow
Dr. Isik received her Ph.D. in Cancer Biology from the University of Zurich where she studied the molecular mechanisms underlying the resolution of transcription-dependent replication stress.
Current research: Esin is investigating LINE-1 retrotransposition as an endogenous source of DNA replication stress and genomic instability. Esin’s work is supported by a Postdoc Mobility fellowship from the Swiss National Science Foundation.
Cheuk-Ting Law, Ph.D. Postdoctoral Fellow
Dr. Law received his Ph.D. at the University of Hong Kong where he investigated chromatin remodelers, transcribed regions, and somatically-acquired LINE-1 insertions in liver cancer. During his graduate studies, he obtained an MPhil degree in Computational Biology at the University of Cambridge.
Current research: Dicky is developing new high-throughput approaches to studying how host factors impact LINE-1 insertions. Dicky's work has been supported by a Charles A. King Trust Postdoctoral Research Fellowship and a fellowship award from the American Cancer Society.
Filipe Martins, M.D., Ph.D. Postdoctoral Fellow
Dr. Martins is a medical oncologist who completed his predoctoral studies at the University of Geneva and obtained his M.D. from the University of Lausanne (UNIL). He receievd his Ph.D. at EPFL (Lausanne, CH), where he studied the role of KRAB zinc finger proteins (KZFPs) in diffuse large B-cell lymphoma, focusing on their impact on the cancer epigenome and immune response.
Current research: Filipe is identifying epigenetic regulators controlling transposable element-mediated inflammatory responses and genome stability. He is particularly focused on targeting 'viral mimicry' pathways as a therapeutic strategy.
Filipe's work is supported by a Postdoc Mobility fellowship from the Swiss National Science Foundation.
Dr. Martins is a medical oncologist who completed his predoctoral studies at the University of Geneva and obtained his M.D. from the University of Lausanne (UNIL). He receievd his Ph.D. at EPFL (Lausanne, CH), where he studied the role of KRAB zinc finger proteins (KZFPs) in diffuse large B-cell lymphoma, focusing on their impact on the cancer epigenome and immune response.
Current research: Filipe is identifying epigenetic regulators controlling transposable element-mediated inflammatory responses and genome stability. He is particularly focused on targeting 'viral mimicry' pathways as a therapeutic strategy.
Filipe's work is supported by a Postdoc Mobility fellowship from the Swiss National Science Foundation.
Carlos Mendez-Dorantes, Ph.D. Postdoctoral Fellow
Dr. Mendez-Dorantes received his Ph.D. at the City of Hope where he focused on determining the mechanisms of chromosomal deletion rearrangements mediated by repetitive DNA elements in mammalian cells.
Current research: Carlos is investigating the contribution of LINE-1 retrotransposition to DNA replication stress, genome instability, and cancer therapeutic response.
Carlos's work is supported by a Postdoctoral Fellowship Award from the Jane Coffin Childs Memorial Fund for Medical Research, and a Forbeck Scholar Award from the Forbeck Research Foundation.
Audrey Muscato, B.A. Graduate Student
Audrey is a Biological and Biomedical Sciences (BBS) graduate student at Harvard. She received her B.A. in Neuroscience from Bowdoin College. Before starting graduate school, Audrey worked as a Research Associate in the Manguso lab at the Broad Institute, using in vivo CRISPR screens to identify mechanisms of resistance and sensitivity to cancer immunotherapy.
Current research: In the Burns lab, Audrey is interested in how LINE-1 expression alters the immune response to cancer.
Maria Amodeo, B.S. Graduate Student
Maria is a Biological and Biomedical Sciences (BBS) graduate student at Harvard. She received her B.S. in Biology from Emmanuel College (Boston), where she studied pre-mature transcription termination. Following her undergraduate studies, Maria worked as a Research Technician in Dr. Amy S.Y. Lee’s lab at Dana-Farber Cancer Institute. As a technician, she studied how cells employ non-canonical mRNA translation programs in response to chronic endoplasmic reticulum stress.
Current research: Maria is excited about how cellular stress contributes to nuclear architecture alterations and expression of retroelements. To explore these ideas, Maria is working in close collaboration with Dr. Sarah Johnstone.
Maria is a Biological and Biomedical Sciences (BBS) graduate student at Harvard. She received her B.S. in Biology from Emmanuel College (Boston), where she studied pre-mature transcription termination. Following her undergraduate studies, Maria worked as a Research Technician in Dr. Amy S.Y. Lee’s lab at Dana-Farber Cancer Institute. As a technician, she studied how cells employ non-canonical mRNA translation programs in response to chronic endoplasmic reticulum stress.
Current research: Maria is excited about how cellular stress contributes to nuclear architecture alterations and expression of retroelements. To explore these ideas, Maria is working in close collaboration with Dr. Sarah Johnstone.
Jupiter Kalinowski, B.A. Research Technician
Jupiter received their B.A. from Bennington College, where they pursued and defended a self-designed course of study focused on microbiology and practical methods in biomedical research. During their senior year at Bennington, they completed a thesis research project exploring non-canonical ubiquitin proteasome pathway degradation of proteins in yeast.
Current Research: In the Burns lab, Jupiter is working to develop and characterize new experimental models of LINE-1, as well as conducting forward genetic CRISPR screens to identify novel regulators of LINE-1 expression in human cells.
Olympia Hatzilambrou, A.B. Research Technician
Olympia received her A.B. in Integrative Biology from Harvard University with secondary studies in Music, Language Citation, and Ancient Greek. During her senior year, she completed a senior thesis in the Girguis Lab at Harvard University studying the evolutionary dynamics of bacterial anti-phage defense systems.
Current Research: Olympia is working to develop new high-throughput technologies for the sequencing of LINE-1 transcripts, and methods for their analysis.
Anirudh Sudarshan, B.S.A. Research Technician
Anirudh received his B.S.A. from the University of Texas at Austin, where he majored in Neuroscience.
Current Research: Anirudh is interested in the expression of ORF1p and ORF2p, the two retrotransposition-critical proteins encoded by LINE-1, and their roles in cancer biology, with a particular focus on ovarian cancers.
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Alumni Postdoctoral Fellows Tatiana Cajuso, Ph.D. Martin Taylor, M.D., Ph.D. Lindsay Payer, Ph.D. Nemanja Rodić, M.D., Ph.D. Chunhong Liu, Ph.D. Graduate Students Daniel Ardeljan, M.D., Ph.D. Wan Rou Yang, M.D., Ph.D. Cheng Ran (Lisa) Huang, Ph.D. Medical Students Maria Kryatova, M.D. Nicolas Giraldo-Castillo, M.D., Ph.D. |
Undergraduates Ally Moyer Chloe Pacyna JaNiece Walker Lab Technicians Jack Heaps Phil Schofield Jared Steranka Peilin Shen William Wu Reema Sharma David Husband Anna Schneider |