Welcome to the Burns Lab
The majority of our genome is highly repetitive sequence derived from the activities of self-propagating retrotransposons. Research in our lab focuses on roles these mobile genetic elements play in human disease. Despite their enormous impact on genome composition over evolutionary time and across virtually all eukaryotic taxa, transposons are often presumed to be inert, non-functional ‘junk DNA’. Our work is challenging that assumption.
Our laboratory was one of the first to develop a targeted method for mapping mobile DNA insertion sites in the human genome, which underscored that these are a significant source of structural variation (Cell, 2010). We have described the aberrant expression of Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) in a wide array of human cancers (American Journal of Pathology, 2014), and shown that this expression is associated with somatically-acquired LINE-1 insertions in cancer genomes in pancreatic ductal adenocarcinomas (Nature Medicine, 2015) and high grade serous ovarian cancers (Proceedings of the National Academy of Sciences, 2017). We have ongoing projects focused on the functional consequences of inherited mobile element insertions (Proceedings of the National Academy of Sciences, 2017) and LINE-1 expression in cancers (Nature Structural and Molecular Biology, 2020).
We invite you to explore our webpage, read about our work on mobile DNAs, and visit our laboratory in the Department of Pathology at the Dana-Farber Cancer Institute.
News
January 2023
Thrilled to team up with Ömer Yilmaz and his lab at MIT for a Footbridge project on LINE-1 in colon cancer. Congratulations to Marty Taylor and Tatiana Cajuso Pons!
January 2023
Excited to share new data that LINE-1 ORF1p, our "hallmark of cancer" is detectable in the peripheral blood!
Now on BioRxiv. Congratulations to Marty Taylor and Connie Wu!
November 2022
Congratulations to Dr. Tatiana Cajuso Pons who was named a Helen Gurley Brown fellow at Dana-Farber Cancer Institute!
October 2022
Congratulations to Dr. Carlos Mendez-Dorantes for his participation in the Forbeck Foundation Scholars Program, and his presentation at the annual Scholars Retreat!
October 2022
Congratulations to Dr. Jennifer Karlow for her postdoctoral fellowship award from the American Cancer Society!
October 2022
We're on our way to Cold Spring Harbor Labs for the Transposable Elements meeting. Congratulations to all the poster presenters from the Burns lab, and to Kathy who will give the opening night's Keynote address.
June 2022
We look forward to welcoming Dr. Esin ışık next month and congratulate her on her Postdoc Mobility Grant from the Swiss National Science Foundation! Esin joins the lab after completing her Ph.D. in cancer biology at the University of Zurich with Dr. Pavel Janscak.
June 2022
Congratulations to Dr. Jennifer Karlow for her travel award to the FASEB Mobile DNA meeting in Ireland and support for her fellowship from the Harvard Medical School T32 Training Grant in Genetics!
May 2022
Welcome to Dr. Tatiana Cajuso Pons! Tatiana joins the lab after completing her Ph.D. studying the genomic impact of LINE-1 in colon cancer at the University of Helsinki with Dr. Lauri Aaltonen.
April 2022
Honored to share this Perspective on Repetitive DNA in Disease for Science.
February 2022
Welcome to Dr. Jennifer Karlow! Jennifer joins the lab after completing her Ph.D. studying epigenetic contributions to cancer development and dissemination at Washington University with Dr. Ting Wang.
January 2022
Welcome to Dr. Cheuk Ting ( Dicky ) Law! Dicky joins the lab after completing his Ph.D. studying LINE-1 elements in cancer at the University of Hong Kong with Dr. Chun Ming (Jack) Wong and Prof. Oi Lin ( Irene ) Ng.
December 2021
Congratulations to Lindsay Payer! Her paper on functions of Alu variants is out in Genome Research!
Our laboratory was one of the first to develop a targeted method for mapping mobile DNA insertion sites in the human genome, which underscored that these are a significant source of structural variation (Cell, 2010). We have described the aberrant expression of Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) in a wide array of human cancers (American Journal of Pathology, 2014), and shown that this expression is associated with somatically-acquired LINE-1 insertions in cancer genomes in pancreatic ductal adenocarcinomas (Nature Medicine, 2015) and high grade serous ovarian cancers (Proceedings of the National Academy of Sciences, 2017). We have ongoing projects focused on the functional consequences of inherited mobile element insertions (Proceedings of the National Academy of Sciences, 2017) and LINE-1 expression in cancers (Nature Structural and Molecular Biology, 2020).
We invite you to explore our webpage, read about our work on mobile DNAs, and visit our laboratory in the Department of Pathology at the Dana-Farber Cancer Institute.
News
January 2023
Thrilled to team up with Ömer Yilmaz and his lab at MIT for a Footbridge project on LINE-1 in colon cancer. Congratulations to Marty Taylor and Tatiana Cajuso Pons!
January 2023
Excited to share new data that LINE-1 ORF1p, our "hallmark of cancer" is detectable in the peripheral blood!
Now on BioRxiv. Congratulations to Marty Taylor and Connie Wu!
November 2022
Congratulations to Dr. Tatiana Cajuso Pons who was named a Helen Gurley Brown fellow at Dana-Farber Cancer Institute!
October 2022
Congratulations to Dr. Carlos Mendez-Dorantes for his participation in the Forbeck Foundation Scholars Program, and his presentation at the annual Scholars Retreat!
October 2022
Congratulations to Dr. Jennifer Karlow for her postdoctoral fellowship award from the American Cancer Society!
October 2022
We're on our way to Cold Spring Harbor Labs for the Transposable Elements meeting. Congratulations to all the poster presenters from the Burns lab, and to Kathy who will give the opening night's Keynote address.
June 2022
We look forward to welcoming Dr. Esin ışık next month and congratulate her on her Postdoc Mobility Grant from the Swiss National Science Foundation! Esin joins the lab after completing her Ph.D. in cancer biology at the University of Zurich with Dr. Pavel Janscak.
June 2022
Congratulations to Dr. Jennifer Karlow for her travel award to the FASEB Mobile DNA meeting in Ireland and support for her fellowship from the Harvard Medical School T32 Training Grant in Genetics!
May 2022
Welcome to Dr. Tatiana Cajuso Pons! Tatiana joins the lab after completing her Ph.D. studying the genomic impact of LINE-1 in colon cancer at the University of Helsinki with Dr. Lauri Aaltonen.
April 2022
Honored to share this Perspective on Repetitive DNA in Disease for Science.
February 2022
Welcome to Dr. Jennifer Karlow! Jennifer joins the lab after completing her Ph.D. studying epigenetic contributions to cancer development and dissemination at Washington University with Dr. Ting Wang.
January 2022
Welcome to Dr. Cheuk Ting ( Dicky ) Law! Dicky joins the lab after completing his Ph.D. studying LINE-1 elements in cancer at the University of Hong Kong with Dr. Chun Ming (Jack) Wong and Prof. Oi Lin ( Irene ) Ng.
December 2021
Congratulations to Lindsay Payer! Her paper on functions of Alu variants is out in Genome Research!
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