Burns Lab for Research on Repetitive DNAs and Transposable Elements
Welcometo the Burns Lab
The majority of our genome is highly repetitive sequence derived from the activities of self-propagating retrotransposons. Research in our lab focuses on roles these mobile genetic elements play in human disease. Despite their enormous impact on genome composition over evolutionary time and across virtually all eukaryotic taxa, transposons are often presumed to be inert, non-functional ‘junk DNA’. Our work is challenging that assumption.
We invite you to explore our webpage, read about our work on mobile DNAs, and visit our laboratory in the Department of Pathology at the Dana-Farber Cancer Institute.
News December 2023 Congratulations to Marty Taylor! He led a collaborative team to report the structure of ORF2p reverse transcriptase - out now in Nature! This animation describes activities of the protein.
December 2023 Congratulations to Carlos Mendez-Dorantes! His review on LINE-1 biology is out in Genes & Development!
November 2023 Congratulations to Dr. Dicky Law for his postdoctoral fellowship award from the American Cancer Society!
October 2023 Welcome to Tomohiro ( Tom ) Kitano! Tom joins the lab after completing his Ph.D. studies on transposable element expression in early development with Dr. Haruhiko Siomi at Keio University School of Medicine in Japan.
September 2023 Congratulations to Marty Taylor and Connie Wu! Their paper on ORF1p as a circulating cancer biomarker is out in Cancer Discovery!
September 2023 We're on our way to Canada for the Transposable element Keystone Symposium! Congratulations to Marty who will give a talk on the structure of the ORF2p reverse transcriptase, and to Kathy who organized the meeting with Drs. Arkhipova and Malik. Check out the meeting report at Mobile DNA.
August 2023 Congratulations to Dr. Dicky Law for his postdoctoral fellowship award from the Charles A. King Trust!
June 2023 Welcome to Aidan Burn! Aidan joins the lab after completing his Ph.D. studies on endogenous retroviruses with John Coffin's lab at Tufts University.
May 2023 We're on our way to Italy for the Cancer Genetics and Epigenetics Gordon Research Conference! Congratulations to Jennifer and Tatiana who will give talks from the Burns lab, and to Kathy who will give one of the Keynote addresses.
March 2023 Join us right here in the Jimmy Fund Auditorium to hear Kathy's Keynote at the 2023 Center for Cancer Genomics Symposium!
January 2023 Thrilled to team up with Ömer Yilmaz and his lab at MIT for a Footbridge project on LINE-1 in colon cancer. Congratulations to Marty Taylor and Tatiana Cajuso Pons!
January 2023 Excited to share new data that LINE-1 ORF1p, our "hallmark of cancer" is detectable in the peripheral blood! Now on BioRxiv. Congratulations to Marty Taylor and Connie Wu!
November 2022 Congratulations to Dr. Tatiana Cajuso Pons who was named a Helen Gurley Brown fellow at Dana-Farber Cancer Institute!
October 2022 Congratulations to Dr. Carlos Mendez-Dorantes for his participation in the Forbeck Foundation Scholars Program, and his presentation at the annual Scholars Retreat!
October 2022 Congratulations to Dr. Jennifer Karlow for her postdoctoral fellowship award from the American Cancer Society!
October 2022 We're on our way to Cold Spring Harbor Labs for the Transposable Elements meeting. Congratulations to all the poster presenters from the Burns lab, and to Kathy who will give the opening night's Keynote address.
June 2022 We look forward to welcoming Dr. Esin ışık next month and congratulate her on her Postdoc Mobility Grant from the Swiss National Science Foundation! Esin joins the lab after completing her Ph.D. in cancer biology at the University of Zurich with Dr. Pavel Janscak.
June 2022 Congratulations to Dr. Jennifer Karlow for her travel award to the FASEB Mobile DNA meeting in Ireland and support for her fellowship from the Harvard Medical School T32 Training Grant in Genetics!
May 2022 Welcome to Dr. Tatiana Cajuso Pons! Tatiana joins the lab after completing her Ph.D. studying the genomic impact of LINE-1 in colon cancer at the University of Helsinki with Dr. Lauri Aaltonen.
April 2022 Honored to share this Perspective on Repetitive DNA in Disease for Science.
February 2022 Welcome to Dr. Jennifer Karlow! Jennifer joins the lab after completing her Ph.D. studying epigenetic contributions to cancer development and dissemination at Washington University with Dr. Ting Wang.
January 2022 Welcome to Dr. Cheuk Ting ( Dicky ) Law! Dicky joins the lab after completing his Ph.D. studying LINE-1 elements in cancer at the University of Hong Kong with Dr. Chun Ming (Jack) Wong and Prof. Oi Lin ( Irene ) Ng.
December 2021 Congratulations to Lindsay Payer! Her paper on functions of Alu variants is out in Genome Research!